ESR1 and breast neoplasm: For instance, SAS can inhibit the system Xc- to enhance ferroptosis in various breast tumor cells, especially in cells with low estrogen receptor expression (Yu H.C. et al., 2019), exosome-based erastin (erastin@FA-Exo) can kill TNBC cells by promoting depletion of glutathione and excess production of ROS (Limoni et al., 2019).