GPX4 and lung cancer: Zhang et al. (2020) detected that higher expression of GPX4 was associated with a higher probability of drug resistance, but inhibiting GPX4 maintained the anti-tumor effect of cisplatin (Deng et al., 2021). Additionally, there were many other agents regulating ferroptosis through various mechanisms in lung cancer. For example, both zinc (Palmer et al., 2019), and celastrol (Liu et al., 2021) can induce ferroptosis by increasing the level of ROS. Additionally, Erianin (Chen P. et al., 2020) can trigger ferroptosis in a calcium/calmodulin-related manner.