The progressive growth of the tumor eventually leads to intratumoral hypoxia, which induces hypoxia-inducible factor-1 (HIF-1) that in turn upregulates multiple target genes, such as the potent proangiogenic factor vascular endothelial growth factor (VEGF), promoting EC proliferation (Carmeliet, 2005; Schito and Semenza, 2016). Here, VEGFA is linked to neoplasm.