VEGFA and neoplasm: Therapeutic agents targeting tumor angiogenesis, such as anti-VEGF or tyrosine kinase inhibitors, have been developed, initially with promising results; however, these therapies showed limited clinical success due to drug resistance and high toxicity, not predicted by the preclinical models employed (Bergers and Hanahan, 2008; Jain, 2014; Aalders et al., 2017).