A study by Yao, in 2020, further demonstrated that hesperidin effectively inhibits the proliferation of NSCLC cells (A549 and H460) by inhibiting the SRC3-mediated ubiquitination of IGF-1R-PI3K-AKT signaling to induce apoptosis and exert an inhibitory effect on the tumor growth in NSCLC (Yao et al., 2020). This evidence concerns the gene AKT1 and non-small cell lung carcinoma.