In proteomics, a total of 32 and 20 differential expressed proteins were identified in T2D and PDB groups compared to the HC group, which were mainly localized in blood microparticle, immunoglobulin complex, protein–lipid complex, and vesicle lumen components, and involved in antigen binding, immunoglobulin receptor binding, protein activation cascade, complement activation, receptor-mediated endocytosis, and phagocytosis pathways. Here, MPIG6B is linked to type 2 diabetes mellitus.