As shown in Figure 6B, the N-glycopeptides NCGVN174CSGDVFTALIGEIASPNYPKPYPENSR-HexNAc4Hex5-NeuAc1Fuc2 from the C1s protein, NN385LTTYK-HexNAc4Hex5NeuAc2Fuc1 from the MASP1 protein, and IVLDPSGSMNIYLVLDGSDSIGASN285FTGAK-HexNAc4Hex5NeuAc1Fuc2 from the CFB protein, all of which modified by fucosylated glycans, were clearly down-regulated in the plasma of T2D patients. This evidence concerns the gene CFB and type 2 diabetes mellitus.