It is worthy to note that TLR4 seems to have a crucial role in NEC development (38, 39): its activation inhibits enterocyte migration and leads to apoptosis in mice, via NFκB pathway, while its inhibition in the intestinal epithelium of mice and cell cultures prevents NEC development, weakening the degree of enterocyte apoptosis (40, 41). This evidence concerns the gene NFKB1 and necrotizing enterocolitis.