ATAD2 has a ATP-binding site and ATPase activity, regulating the assembly of protein complexes (Morozumi et al., 2016), as CREB-binding promoter region or regulating histone hyperacetylation (Koo et al., 2016; Lazarchuk et al., 2020), suggesting the ATAD2/miR-548d can alter gene transcription during infection. The gene discussed is CREB1; the disease is infection.