PRF1 and cutaneous leishmaniasis: In a recent transcriptomic study of skin samples of cutaneous leishmaniasis patients, delayed or absence of cure was correlated with higher expression of gene sets related to the cytolytic pathway, including mRNAs for granzyme (GZMB), perforin (PRF1), and granulysin (GNLY) (Amorim et al., 2019).