As ACE2 is critical to SARS-CoV-2 infection, an imbalance in the RAS, with a shift towards ACE/Ang II and suppressing ACE2/Ang- (Drosten et al., 2003; Zaki et al., 2012; Chakravarty et al., 2020; Huang et al., 2020; Li et al., 2020; Shang et al., 2020; Zhou et al., 2020), may be an important mediator of COVID-19 pathophysiology (South et al., 2020). This evidence concerns the gene ACE2 and COVID-19.