Deregulation of the RAS pathway leads to an increase in the level of AngII, which interacts with its angiotensin II type 1 receptor (AT1R), thus facilitating the activation of various intracellular pathways involved in the remodelling of the heart, vascular disease and endothelial dysfunction (Muslin, 2008; Wehbe et al., 2020). Here, AGTR1 is linked to endothelial dysfunction.