A functional experiment found that overexpression of ALKBH5 inhibited colon cancer cells invasion in vitro and metastasis in vivo (14); the m6A modification of the PD-L1 mRNA and the binding of FTO to the PD-L1 mRNA was testified in HCT-116 cell line by RNA immunoprecipitation assay which indicated that FTO could regulate PD-L1 expression in colon cancer cells (15); and lncRNA OCC-1 suppresses cell growth through destabilizing HuR (ELAVL1) protein in colorectal cancer (16); METTL3 could maintain colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation (17). Here, CD274 is linked to colorectal cancer.