Likewise, it is implied that IL-1β contributes to an immunosuppressive TME and favors tumor growth; inhibition of IL1β drives the accumulation of CD8+ T cells at tumor sites, which subsequently activates TAMs and induces tumor regression; nevertheless, depletion of TAMs with CSF-1R inhibitor can abolish tumor shrinkage caused by IL-1β deficient (159). This evidence concerns the gene CSF1R and neoplasm.