IFNG and neoplasm: On the other hand, TAMs can be activated or reprogramed to trigger anti-tumor activities by secreting immunocidal molecules (e.g. ROS) and inflammatory cytokines (e.g. IFN-γ and TNF-α), or directly phagocytosing neoplastic cells and recruiting of tumor-killing leukocytes or activating adaptive immune responses (10, 17).