JAK2 and neoplasm: In a model of colorectal cancer, for example, research has shown that TAMs were induced by tumor cells to secrete IL-6 that drove EMTs in tumor cells via the JAK2/STAT3/FoxQ1 axis, while in turn CCL2 produced by tumor cells recruited TAMs into the tumor microenvironment to form a vicious cycle that ultimately led to distant metastasis of colon cancer cells, and experiments in vivo revealed that inhibition of IL-6 significantly reduced tumor metastases (73).