For example, in hepatocellular carcinoma, blockade of the RBPJ-regulated Notch signaling pathway reduced infiltration of monocyte-derived TAMs into tumor tissues, but activated the WNT/β-catenin signaling pathway, leading to massive infiltration of Kupffer cell-derived TAMs into hepatocellular carcinoma tissues, which also upregulated anti-inflammatory cytokine IL-10 levels, downregulated IL-12 levels, and further facilitated tumor proliferation (33). The gene discussed is RBPJ; the disease is hepatocellular carcinoma.