Furthermore, it was found that CC-motif ligand 2 (CCL2) interacts with its receptor CCR2 to recruit inflammatory monocytes into the TME and become TAMs, which in turn can secrete another chemokine ligand, CCL3, to interact with metastatic cancer cells, improving TAM retention in metastatic foci and supporting tumor growth (76, 78). This evidence concerns the gene CCR2 and neoplasm.