CD40 and neoplasm: As mentioned above, the manipulation of TAMs to exert anti-neoplastic effects has been investigated using different therapeutic approaches, such as CD47-SIRP1a or MHC I- LILRB1inhibitors can restore the ability of TAMs to engulf tumor cells, TLRs and CD40 agonists and other inhibitors can stimulate TAMs to become tumoricidal effector cells.