CD8A and neoplasm: For example, in a model of cervical carcinoma, synthetic long peptide (SLP) vaccines can induce tumor regression not only by inducing cytotoxic CD8+ T cells to infiltrate tumor sites, but also by attracting macrophages by these vaccine-induced T cells; depletion of TAMs with CSF-1R inhibitor abrogates the complete tumor remission elicited by SLP therapy (157).