May affect the epidermal growth factor receptor (EGFR) signaling pathway. Prostaglandin synthesis transactivates the induction of EGFR phosphorylation, thereby contributing to pancreatic tumor proliferation.Intrinsic cell role for COX-2 in tumor initiation and progression through activation of the PI3K/AKT pathway. The gene discussed is PTGS2; the disease is pancreatic neoplasm.