Likewise, HIF-1α is a significant regulator of oxygen homeostasis within cells (119), activating multiple genes involved in vasodilatation, angiogenesis, neovascularization, cell survival, invasion, and tumor metastasis (120). HIF-1α protein is overexpressed in multiple types of human cancer, including lung, prostate, breast, pancreas, colon carcinoma, and regional and distant metastases (120, 121). This evidence concerns the gene HIF1A and neoplasm.