Likewise, HIF-1α is a significant regulator of oxygen homeostasis within cells (119), activating multiple genes involved in vasodilatation, angiogenesis, neovascularization, cell survival, invasion, and tumor metastasis (120). HIF-1α protein is overexpressed in multiple types of human cancer, including lung, prostate, breast, pancreas, colon carcinoma, and regional and distant metastases (120, 121). Here, HIF1A is linked to colon carcinoma.