However, as a result of signals such as NF-κB, TGF-β, and HIF-1 in the cancer context, they also promote the activation of the snail and Zeb transcription factors families. This activation allows the up-regulation of the Rac1/RhoA and PI3K pathways (137), which would indicate the promotion of the mesenchymal phenotype necessary for cell migration. This evidence concerns the gene HIF1A and cancer.