Within the TME, the COX-2 overexpression orchestrates this inflammatory profile in various types of solid malignant tumors such as gastric cancer (57), colorectal cancer (58), hepatocellular carcinoma (59), melanoma (60), pancreatic cancer (36), endometrial cancer (61), and squamous cell carcinoma of the neck and head (43). The gene discussed is PTGS2; the disease is familial pancreatic carcinoma.