Furthermore, tumors with deleted BAP1 showed a lower proportion of plasma cells, natural killer (NK) cells, and B cells but higher mast cell and T cell infiltration, as well as higher expression of genes with a known role in immune checkpoint modulation (PD1, PD-L1 CD80, CTLA4, LAG3, and ICOS), compared with tumor with wild-type BAP1. The gene discussed is CD274; the disease is neoplasm.