Twenty-five (37.3%) out 67 probands, 17 of which were affected by BC and eight by OC, harbored VUS in BRCA1 gene; 37 (55.2%) subjects, 24 of which were with BC and 13 with OC in BRCA2 gene, whereas four (6.0%) BC women carried simultaneously two VUS in BRCA2, and one (1.5%) BC patient had VUS both in BRCA1 and BRCA2. Twenty-one (35.6%) out of 59 different variants were located on BRCA1 gene, whereas 38 (64.4%) have been identified on BRCA2 gene (Tables 2 and 3). This evidence concerns the gene BRCA2 and breast cancer.