In our colon-specific network, the lncRNA MIR17HG sponges hsa-miR-130a and interacts with RPS6KA5. Hsa-miR-1271-5p, hsa-miR-130a, SOX12, ANKRD6, TMEM198, STC1, H19, and NRG1 all presented potential risk factors for colon cancer. Here, TMEM198 is linked to malignant colon neoplasm.