NLRP3 and heart failure: Several studies indicates that polydatin is able to reduce the propagation (scavenger-scavenger effect) of reactive oxygen species, the production of nitric oxide and pro-inflammatory cytokines by inhibiting the NLRP3 inflammasome and the signaling of the NF-kB, both factors involved in cancer survival and cardiotoxic events like myocardial fibrosis, atherosclerosis and heart failure (18–20).