(2020) in complex karyotype AML, it was observed that asparaginase mediated glutamine depletion and subsequent inhibition of 4EBP1 and reduced MCL1 expression are the mostly likely underlying mechanisms for synergistic effect observed in BCL2 inhibition with venetoclax and asparaginase combination (38). Here, EIF4EBP1 is linked to acute myeloid leukemia.