EPCAM and breast carcinoma: found that effector NK-92 cells which co-expressed epithelial cell adhesion molecule (EpCAM), a type I transmembrane glycoprotein identified as a TAA—specific CAR and IL-15 could proliferate without exogenous cytokines in vitro and exhibited potent and specific cell-killing functions against EpCAM-expressing breast carcinoma cells those were resistant to unmodified NK cells-induced cytotoxicity (95).