In addition to the releases of perforin and granzymes for tumor cell elimination, NK cells exert antibody-dependent cellular cytotoxicity (ADCC) by the membrane receptor CD16 or apoptotic axis intermediated by Fas ligand (FasL) or TNF-related apoptosis-inducing ligand (TRAIL) (Figure 1) (12, 13). Here, TNFSF10 is linked to neoplasm.