Likewise, MSLN-specific CAR-NK-92MI cells selectively eliminated pancreatic cancer lines in vitro by secreting IFN-γ and granzyme B (143), and also Roundabout homolog 1 (Robo1)-specific CAR-NK cells demonstrated great cytotoxicity against pancreatic ductal adenocarcinoma (PDAC) in an orthotopic nude mouse model (102). The gene discussed is GZMB; the disease is familial pancreatic carcinoma.