The use of logic-gated (log) GPC3-synNotch-inducible CD147-CAR for reducing on-target/off-tumor toxicity in HCC showed that LogCD147-CAR could selectively eliminate dual antigen (GPC3-positive CD147-positive), but not single antigen (GPC3-negative CD147-positive) positive HCC cells without any serious on-target/off-tumor toxicity in a human CD147 transgenic murine model (100). This evidence concerns the gene GPC3 and hepatocellular carcinoma.