MALAT1/miR-101, MALAT1/miR-203, TUSC7/miR-10a, NEAT1/let-7g-5p, AC003092.1/miR-195, SNHG15/miR-627, HOTAIR/miR-519a-3p, HOTAIR/miR-125, KCNQ1OT1/miR-761, NCK1-AS1/miR-137, NCK1-AS1/miR-22-3p and HOXD-AS1/miR-204 are among lncRNA/miRNA pairs that regulate resistance to chemotherapeutic agents in glioma/glioblastoma. This evidence concerns the gene HOTAIR and central nervous system cancer.