Type I LCNECs with high neuroendocrine expression and, similar to SCLC, a profile of ASCL1 high/DLL3 high/NOTCH low, and type II LCNECs with reduced expression of neuroendocrine genes and a pattern of ASCL1 low/DLL3 low/NOTCH high (21). This evidence concerns the gene ASCL1 and small cell lung carcinoma.