A study from Japan performed genomic profile of SCLC and LCNEC and found similar genomic changes in the PI3K/AKT/mTOR pathway: PI3KCA (3%), PTEN (4%), AKT2 (4%) RICTOR (5%), mTOR (1%) and alterations in EGFR (1%), ERBB2 (4%) and FGFR1 (5%) in LCNEC compared with 4, 6, 2, 6, 1, 1 and 3% in SCLC respectively. Here, MTOR is linked to large cell neuroendocrine carcinoma.