Another study demonstrated that HDAC5 recruited macrophages to the tumor microenvironment through the Suppressor of cytokine signaling 3 (Socs3)/C-C motif chemokine ligand 2 (CCL2) axis and promoted pancreatic cancer via TGF-β-dependent paracrine signaling (63). Here, SOCS3 is linked to familial pancreatic carcinoma.