Besides, HDAC3 and HDAC5 had copy number gain during HCC progression, panobinostat might inhibit HDAC3 and HDAC5 to decrease proliferation and induce apoptosis and autophagy of HCC, and this anticancer effect could be augmented by combination therapy with panobinostat and sorafenib (74). The gene discussed is HDAC5; the disease is hepatocellular carcinoma.