In LUSC, we have found that NUF2 was positively related with tumor purity weakly (cor = 0.388, P = 1.25e−18), negatively correlated with CD4+ T cells (partial.cor = −0.213, P = 2.96e−06) and macrophages weakly (partial.cor = −0.254, P = 1.88e−08), and negatively correlated with dendritic cells (partial.cor = −0.132, P = 4.01e−03) and neutrophils very weakly (partial.cor = −0.137, P = 2.83e−03). This evidence concerns the gene NUF2 and neoplasm.