It is important to note that by using two stable 4T1 cell lines with Ldha knock-down (4T1-shLdha1 and 4T1-shLdha3), we found that tumor grew significantly more slowly in both 4T1-shLdha groups compared with the control mice after tumor cells inoculated in the 4th breast fat pad of Balb/c mice, and tumor weight at 25th day was much lower as well (Figures 1E–G). This evidence concerns the gene LDHA and neoplasm.