At this point, is important to notice that under in vitro prolonged hypoxic stress (48-72h, <1% pO2), the gene BNIP3 (Bcl-2/adenovirus E1B 19kDa-interacting protein 3), a pro-apoptotic Bcl-2 family member, is upregulated, leading to hypoxia-dependent ACD in GBM cells (72). Here, BCL2 is linked to glioblastoma.