IL6 and glioblastoma: It is also conceivable that autophagy may contribute to the increased production of multiple pro-invasive cytokines, including interleukin-6 (IL-6) and -8 (IL-8), which, in turn, may reactivate a pro-invasive and GSC transcriptional programs, leading GBM cells to the “go” state, allowing them to migrate away from cytotoxic niches towards a supportive microenvironment (69, 82).