Decorin (DCN), a member of the small leucine-rich proteoglycans (PGs) family, has a vital role in the hypoxia-dependent activation of autophagy and anti-glioma therapy resistance, mainly due to their binding to VEGFR2 expressed by vECs, particularly in PNNs of glioma samples, or with the binding to c-Met and EGFR receptors expressed by GBM cells (83, 84). The gene discussed is KDR; the disease is central nervous system cancer.