Patients with elevated CEA, CYFRA21-1, NSE, CA125, CA153 and CA199 all showed worse RFS compared with those with normal serum tumor markers (CEA: P<0.0001, CYFRA21-1: P<0.0001, NSE: P=0.0027, CA125: P<0.0001, CA153: P<0.0001, CA199: P<0.0001) (Figure 5). Here, ENO2 is linked to neoplasm.