MYC and ovarian cancer: To further confirmed the potential role of PHGDH in ovarian cancer, PHGDH was ectopically overexpressed in SKOV3 and A2780 cells infected with lentivirus containing PHGDH labeled with Myc epitope (Myc-PHGDH) compared to SKOV3 and A2780 cells infected with the empty pGCLV-GV166 lentivirus vector (empty) (Figure 3A).