Enrichment of PHGDH mRNA by pan-Ago was not significantly different between platin-resistant and platin-sensitive SKOV3 (Figure 5C) and A2780 (Figure 5D) cells, indicating that miRISCs might not be implicated in differential translation of PHGDH between platin-resistant and platin-sensitive ovarian cancer cells. The gene discussed is FBXW7; the disease is ovarian carcinoma.