To investigate if the mutp53-pSTAT3 complex can directly regulate the phosphorylation status of STAT3 as shown in CRC (26), we depleted mutp53 in MIA-PACA-2, PA-TU-8988T, PANC-1, BXPC-3 and PA-TU-8902 cells (Figure 4E and Supplementary Figure 2B). The gene discussed is STAT3; the disease is colorectal carcinoma.