RBP1 and gastric carcinoma: For example, in EBV-associated gastric carcinoma, hypermethylation of RBP1 in the promoter region, correlated with the upregulation of RBP1, which demonstrated that patients with CpG island methylator phenotype-high (CIMP-H) have poorer survival than those with CIMP-low in gastric carcinoma (49).