LEP and stroke disorder: Leptin is an essential determining factor in the occurrence, severity, degree, and complexity of lesions in patients with CAD [10]. Leptin is also implicated in myocardial infarction (MI) and stroke in men and women independently of conventional cardiovascular risk factors and BMI in the US population [11]. A study conducted by Chai et al. observed no statistically significant relationship between leptin and CAD; however, they concluded that high leptin levels in men should not be ignored [12].