ASPN: asporin; CILP: cartilage intermediate layer protein; IDD: intervertebral disc degeneration; IGF1R: Insulin-like growth factor 1 receptor; LDD: lumbar disc degeneration; MMP9: matrix metallopeptidase 9; THBS2: thrombospondin 2. Here, IGF1R is linked to intervertebral disk degenerative disorder.