A 1562C/T polymorphism in the MMP9 promoter region was studied in Chinese males with LDD where there was an association between the CC/TT MMP9 genotype in relation to MRI evidence of severe IDD [23]. Additionally, the MMP9 rs17576 (GG) genotype was recently studied through a meta-analysis analyzing two articles that concluded a positive association between the rs17576 polymorphism and increased risk of DDD [12]. This evidence concerns the gene MMP9 and intervertebral disk degenerative disorder.