ASPN: asporin; CILP: cartilage intermediate layer protein; IDD: intervertebral disc degeneration; IGF1R: Insulin-like growth factor 1 receptor; LDD: lumbar disc degeneration; MMP9: matrix metallopeptidase 9; THBS2: thrombospondin 2. The gene discussed is ASPN; the disease is intervertebral disk degenerative disorder.