HSP90, a molecular chaperone of FK-506 binding protein 5 (FKBP5), coordinates with FKBP5 to regulate glucocorticoid receptor (GR) activity; both are factors of several affective disorders, including anxiety, depression, and post-traumatic stress disorder (PTSD) (Criado-Marrero et al., 2018). The gene discussed is NR3C1; the disease is post-traumatic stress disorder.