Previous studies have revealed that lncRNAs participated in different biological processes such as immune regulation (Denaro, Merlano & Lo Nigro, 2019), DNA repair and cell cycle (Hu et al., 2018; Majidinia & Yousefi, 2016), and metabolism (Denaro, Merlano & Lo Nigro, 2019), etc. Among this FRlncRNAs signature (RHPN1-AS1, MAPKAPK5-AS1, and PART1) of our study, RHPN1-AS1 could facilitate cell proliferation, and invasion via activating PI3K/AKT/mTOR pathway in HCC (Song et al., 2020). This evidence concerns the gene AKT1 and hepatocellular carcinoma.