AGER and Sepsis: In a murine model of sepsis, RAGE ligand HMGB1 derived from neutrophil extracellular traps (NETs), acting via RAGE and dynamin-dependent signaling, and the downstream molecular pathways, drove macrophage pyroptosis through cathepsin B (CatB) release from ruptured lysosomes, followed by the formation of the pyroptosome and caspase-1 activation [45].