Additionally, AIT is believed to switch the balance of TH1/TH2 responses towards a regulatory TH1 response, characterized by the release of cytokines IL-12, IL-10, and IFN-γ, among others.15, 16, 17 Given their relevance, this study focused on assessing these immunological parameters in patients receiving AIT with Acarovac Plus® to treat HDM allergy. The gene discussed is IFNG; the disease is allergic disease.