Binding between the SARS-CoV-2 and ACE2 can lead to alterations in ACE2 signaling pathways, leading to acute damage to the myocardium and lungs; b) systemic inflammation [54]: the most severe forms of COVID-19 are characterized by an acute systemic inflammatory response and cytokine storm, which can lead to multi-organ injury, leading to organ failure. Here, ACE2 is linked to COVID-19.