Although there is an association between hereditary thrombophilias and VTE,systematic work-up for thrombophilias should not be conducted for all women, butrestricted to patients with prior episodes or family history of thrombophilias withgreater potential for complications, such as antithrombin deficiency and homozygosisof factor V Leiden and the 20210 prothrombin mutation, which may need VTEprophylaxis. Here, F2 is linked to Rare hereditary thrombophilia.