PCSK9 and coronary artery disorder: For instance, a rare nonsense variant (i.e., which causes the premature termination of a protein) in the gene PCSK9 was found having a higher allele frequency in African Americans: it was associated with a dramatic reduction in low-density lipoprotein cholesterol concentration (LDLC; 28–40%) (Cohen et al., 2005, 2006) and concomitant decrements in coronary heart disease risk (88%) (Cohen et al., 2006).