The actin-associated formin homology 2 domain containing protein 1 (FHOD1) gene is upregulated in melanomas and modifies proliferation and tumor growth (Peippo et al., 2017), and the HSD11B2 plays a role in metastasis in colorectal cancer (Chen et al., 2020). The gene discussed is HSD11B2; the disease is colorectal cancer.