TLE6 and Infertility: In mice, knockout of certain MEGs, namely, Nlrp2, Mater, Padi6, Floped, and Tle6, leads to infertility or subfertility owing to embryonic arrest (Tong et al., 2000; Li et al., 2008; Yurttas et al., 2008; Yu et al., 2014; Mahadevan et al., 2017).