In mouse models, knockout of the Tle6 gene has no effect on folliculogenesis, oogenesis, and ovulation but instead results in embryonic development arrest at the two-cell stage, and some embryos showed significant fragmentation at embryonic days 2.5 and 3.5, eventually leading to female mice infertility (Li et al., 2008; Yu et al., 2014). Here, TLE6 is linked to Infertility.