Major biological processes and pathways enriched in response to thermal stress included protein folding and refolding, protein phosphorylation, transcription factor binding, immune effector process, negative regulation of cell proliferation, autophagy, apoptosis, protein processing in endoplasmic reticulum, estrogen signaling pathway, pathways related to cancer, PI3K- Akt signaling pathway, MAPK signaling pathway. Here, AKT1 is linked to cancer.