ERCC2 and intervertebral disk degenerative disorder: In addition, circRNA involved in compression-induced damage of NPCs (circRNA-CIDN) (Xiang et al., 2020), circ-4099 (Wang et al., 2018), and circ-ERCC2 (Xie et al., 2019) were all corroborated to mediate the progression of IDD via negatively regulated miRNA expression.