Considering the high prevalence of obesity and comorbidities such as T2DM (Rtveladze et al., 2014) and hypoalphalipoproteinemia in the Mexican population (Hernández-Alcaraz et al., 2020) and that the expression of DPP4 is increased in these abnormalities, the present study aimed to evaluate the association of the DPP4 polymorphisms with the presence of hypoalphalipoproteinemia and with DPP4 levels in a cohort of Mexican individuals. This evidence concerns the gene DPP4 and hypoalphalipoproteinemia.