DPP4 and obesity due to melanocortin 4 receptor deficiency: Moreover, DPP4 is an adipokine with increased expression in obesity (Lamers et al., 2011; Sell et al., 2013), FL (Miyazaki et al., 2012), and type 2 diabetes mellitus (T2DM) (Zhong et al., 2015), abnormalities that coexist with chronic inflammation.