Mutations in PSTPIP1 may cause pyoderma gangrenosum and acne syndrome (PAPA); the PAPA-associated mutations A230T, E250Q, and E250K may increase PSTPIP1 phosphorylation, which further activates the pyrin inflammasome by increasing ASC-mediated inflammasome assembly (63–65). The gene discussed is PSTPIP1; the disease is pyoderma gangrenosum.