NLRP3 and diabetes mellitus: NLRP3 inflammasome activation in inflammatory periodontal tissue can be triggered by local factors such as the crystalline structure of dental calculus, aggravated by systemic factors such as hyperglycemic status of type 2 diabetes mellitus and age-related oxidative stress, or alleviated by 1,25-dihydroxyvitamin D3 (157–162).