NLRP3 and osteomyelitis: The levels of NLRP3 and GSDMD were found to be increased in infectious bone tissue from patients with osteomyelitis compared to those in bone fragments from patients with fractures; moreover, caspase-1 and NLRP3 inhibitors significantly reduce S. aureus-induced osteoblast pyroptosis, restore bone formative properties, and attenuate osteoclast activation in bone marrow macrophages in vitro and decrease bone loss in vivo (150).