NLRP3 (157–162), AIM2 (163, 164), pyrin (165), and noncanonical inflammasomes (166–169) can be activated in a context- and cell type-dependent way. NLRP1 (170–174), NLRP2 (172, 175), NLRP6 (172, 176), and NLRC4 (163, 171) expressions gain controversial results. NOD1 and NOD2 may also participate in periodontitis (177, 178). The gene discussed is NLRC4; the disease is periodontitis.