Oxidative stress induces pyroptosis of osteoblast-like MG63 cells by activating the NLRP3 inflammasome, thereby attenuating bone formation and promoting periodontitis; in contrast, an NLRP3 inhibitor reverses the reduction in osteoblast migration and COL1, RUNX2, and ALP levels (149). The gene discussed is NLRP3; the disease is periodontitis.