Bone autoinflammation in mice with CRMO resulting from Pstpip2 gene mutation may be independent of AIM2 but can be protected by deficiencies in NLRP3/caspase-1 and caspase-8 signaling, suggesting that caspase-8 plays a role in IL-1β processing (317, 318). Here, NLRP3 is linked to chronic recurrent multifocal osteomyelitis.