NLRP6 and acute liver failure: Fitting with a potential role for the microbiota, gut microbiota dysbiosis due to chronic use of antibiotics or proton pump inhibitors was implicated in higher susceptibility to acute liver failure after APAP overdose in humans, which was recapitulated in dysbiotic Nlrp6-/- mice and in WT mice that were transferred faecal microbiota from Nlrp6-/- mice (77).