In particular the observation that patients with allergy showed a decreased frequency of this Th responses-attenuating ILC2 subpopulation and that the induction of IL-10-secreting ILC2s in these patients by allergen immunotherapy was associated with clinical response (98) strongly implicated that targeted enrichment of IL10+KLRG1+ ILC2s could be an attractive, albeit technically challenging therapeutic target to strive for in the future clinical management of asthma patients. The gene discussed is IL10; the disease is asthma.