However, despite the availability of the humanized anti-CCR4 antibody mogamulizumab, which has been clinically approved for the treatment of adult T cell lymphoma (154, 155), till today, there exist no clinical or preclinical in vivo data confirming a clinical benefit of antibody-mediated CCR4 blockade in the therapeutic context of allergic or inflammatory lung disease. Here, CCR4 is linked to adult T-cell leukemia/lymphoma.