NLRP3 and age-related macular degeneration: Furthermore, TRIM31 reduces the risk of other NLRP3 inflammasome-associated diseases such as apical periodontitis (AP, an acute suppurative inflammation caused by endodontic microbial infections) and age-related macular degeneration (AMD, a major cause of blindness in the elderly in developed countries, induced by dysfunction of retinal pigment epithelial cells, which constitute the immune defense barrier of the macula) (46, 47).