Single nucleotide polymorphisms (SNPs) of TRIM31, also called hemochromatosis candidate gene I, are associated with a variety of inflammatory diseases including inflammatory bowel disease (IBD, a chronic nonspecific inflammatory disease characterized by recurrent inflammation of the intestinal mucosa, comprising two main distinctive entities, ulcerative colitis and CD) and irritant contact dermatitis (ICD, a kind of skin inflammatory reaction after contact with exogenous irritants) (42, 43). Here, TRIM31 is linked to inflammatory bowel disease.