AIM2 and type 1 diabetes mellitus: In humans, Aim2 gene expression was increased in the pancreas but not in peripheral blood mononuclear cells (PBMCs) in individuals with T1D compared to healthy controls (55); however, the data from the pancreas was only available in a small group (n=4-8) and thus needs to be confirmed in larger cohorts, ideally separating infiltrating immune cells from the islet β-cells.