CD8A and psoriasis: Given that the studies over the last decade have provided much more consensus on the direct role of CD8+ T cells on psoriasis initiation and maintenance (9, 51) than NK cells (48, 57), it is possible that carriers of KIR2DL2 are at greater risk for developing psoriasis because those individuals are more likely to have enhanced survival of skin resident memory CD8+ T cells that can be activated by dendritic cells and release cytokines such as IL-17.