Using RT-qPCR, we found that ectopic expression of ORF8SARS-CoV-2 significantly inhibited expression of some members of the IFN-stimulated gene (ISG) family including ZBP1 (an innate sensor of viral infection), MX1 and MX2 (host restriction factors of viral replication), and DHX58 (a critical molecule in the RIG-I cytosolic pattern recognition receptor pathway) in A549 cells (Figure 4A). This evidence concerns the gene ZBP1 and viral infectious disease.