In this research, a 17 immune gene survival signature (including RPRM, APOH, SSX1, MSGN1, HPR, ISM2, FGA, LBP, HAS1, CSF2, RETN, CCL2, CCL21, MMP19, PTGIS, F13A1, C1QTNF1) was generated from 401 tumor samples of early stage LUSC. This evidence concerns the gene HPR and neoplasm.