In this research, a 17 immune gene survival signature (including RPRM, APOH, SSX1, MSGN1, HPR, ISM2, FGA, LBP, HAS1, CSF2, RETN, CCL2, CCL21, MMP19, PTGIS, F13A1, C1QTNF1) was generated from 401 tumor samples of early stage LUSC. The gene discussed is RETN; the disease is neoplasm.