Immunological serum profiling revealed that certain biomarkers are virtually uniformly linked to less favorable outcomes (TNFRS12A, TNFRS9, TNFSR21, Gal-1, CD27, MCP family, and CCL23), while others may be related to specific organ injury patterns (CCL4, CD40, CXCL5, and IL-15 for cardiovascular failure; IL-12RB1, KIR3DL1, and CXCL9 for liver failure; CAIX, IL-33, and CXCL9 for kidney failure; GZMA for respiratory failure). Here, CD40 is linked to respiratory failure.