REN and blood coagulation disease: Although similarities and differences in mechanisms of coagulofibrinolytic changes in coronaviruses have been discussed, ACE2 and the renin-angiotensin-aldosterone system (RAAS) is considered one of main mechanisms of coagulopathies in SARS-CoV, SARS-CoV-2, influenza virus, and human coronavirus NL63 infections (13–15).