AGT and blood coagulation disease: The three pathomechanisms of COVID-19 coagulopathy are Ang II-induced coagulopathy, hyperfibrinolysis due to FXII and KKS activation, and DIC, which elicit thromboplasminflammation, leading to systemic inflammation, activation of coagulation and fibrinolysis associated with organ dysfunction, bleeding, and poor outcome (Figure 5).